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NLM234571489 |
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DE-627 |
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20250216135353.0 |
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cr uuu---uuuuu |
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231224s2014 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2013.12.001
|2 doi
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5 |
2 |
|a pubmed25n0781.xml
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|a (DE-627)NLM234571489
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|a (NLM)24434272
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| 035 |
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|a (PII)S1521-6616(13)00320-3
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Doi, Hiroyoshi
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis
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| 264 |
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1 |
|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.04.2014
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| 500 |
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|a Date Revised 20.05.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Published by Elsevier Inc.
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| 520 |
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|a UNLABELLED: Hepatitis C cirrhosis is associated with a profound disappearance of memory B-cells. We sought to determine if this loss is associated with the expansion of the CD27(-)CD21(-) tissue-like memory B-cells with features of B-cell exhaustion. To this end, we quantified the frequency of CD27(-)CD21(-) B-cells in healthy, non-cirrhotic HCV-infected, and cirrhotic patients. We examined the expression of putative inhibitory receptors, the proliferative and immunoglobulin-secreting capacity of CD27/CD21-defined B-cell subsets upon B-cell receptor and/or CD40 stimulation. We found that CD27(-)CD21(-) B-cells are significantly increased in frequency relative to healthy donors in HCV-infected patients. CD27(-)CD21(-) B-cells were hypoproliferative relative to naïve and resting memory B-cells upon agonistic stimulation, but retained similar capacity for antibody secretion
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| 520 |
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|a CONCLUSION: CD27(-)CD21(-) tissue-like memory B-cells with exhausted proliferation circulate at increased frequency in cirrhotic and non-cirrhotic HCV-infected patients. This B-cell subset does not appear anergic, exhibiting immunoglobulin-secreting capacity on CD40 agonism indistinguishable from other CD27/CD21-defined B-cell subsets
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Anergy
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| 650 |
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4 |
|a B-cell
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| 650 |
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4 |
|a CD21
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| 650 |
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4 |
|a Hepatitis C
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| 650 |
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4 |
|a Human
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| 650 |
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4 |
|a Lymphocyte
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| 650 |
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7 |
|a Receptors, Antigen, B-Cell
|2 NLM
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| 650 |
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7 |
|a Receptors, Complement 3d
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 700 |
1 |
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|a Tanoue, Shiroh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kaplan, David E
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 150(2014), 2 vom: 25. Feb., Seite 184-91
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:150
|g year:2014
|g number:2
|g day:25
|g month:02
|g pages:184-91
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2013.12.001
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 150
|j 2014
|e 2
|b 25
|c 02
|h 184-91
|