Endocytic pH-triggered degradation of nanoengineered multilayer capsules

Endocytic pH-triggered degradation of nanoengineered multilayer capsules

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 12 vom: 26. März, Seite 1901-5
1. Verfasser: Liang, Kang (VerfasserIn)
Weitere Verfasser: Such, Georgina K, Johnston, Angus P R, Zhu, Zhiyuan, Ejima, Hirotaka, Richardson, Joseph J, Cui, Jiwei, Caruso, Frank
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't biomaterials drug delivery layer-by-layer nanotechnology polymer capsules Cell-Penetrating Peptides Drug Carriers Nanocapsules mehr... Polymethacrylic Acids poly(2-(diisopropylamino)ethyl methacrylate) poly(MPC-co-MA) Phosphorylcholine 107-73-3
Beschreibung
Zusammenfassung:© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake
Beschreibung:Date Completed 25.11.2014
Date Revised 11.03.2022
published: Print-Electronic
CommentIn: Nanomedicine (Lond). 2014 Apr;9(5):573-6
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201305144