Endocytic pH-triggered degradation of nanoengineered multilayer capsules

Endocytic pH-triggered degradation of nanoengineered multilayer capsules

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 12 vom: 26. März, Seite 1901-5
Auteur principal: Liang, Kang (Auteur)
Autres auteurs: Such, Georgina K, Johnston, Angus P R, Zhu, Zhiyuan, Ejima, Hirotaka, Richardson, Joseph J, Cui, Jiwei, Caruso, Frank
Format: Article en ligne
Langue:English
Publié: 2014
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't biomaterials drug delivery layer-by-layer nanotechnology polymer capsules Cell-Penetrating Peptides Drug Carriers Nanocapsules plus... Polymethacrylic Acids poly(2-(diisopropylamino)ethyl methacrylate) poly(MPC-co-MA) Phosphorylcholine 107-73-3
Description
Résumé:© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake
Description:Date Completed 25.11.2014
Date Revised 11.03.2022
published: Print-Electronic
CommentIn: Nanomedicine (Lond). 2014 Apr;9(5):573-6
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201305144