Propagation-based phase-contrast X-ray microtomography of a cerebral protection device retrieved after carotid artery stenting

Phase-contrast synchrotron X-ray microtomography (pcSyncX) based on the highly coherent X-ray beam has previously been used to visualize the microstructures of biologic specimens, but it has never been used to evaluate embolic debris adherent on a cerebral protection device (CPD). The purpose of thi...

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Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 21(2014), Pt 1 vom: 15. Jan., Seite 215-22
1. Verfasser: Youn, Sung Won (VerfasserIn)
Weitere Verfasser: Kim, Ho Kyun, Kim, Hong Tae, Han, Sung Mi, Do, Jin Kuk, Do, Young Rok, Lee, Hui Joong, Lee, Jongmin, Lim, Jae Hong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article Research Support, Non-U.S. Gov't carotid artery stenting cerebral protection device embolic debris microtomography phase contrast synchrotron X-rays
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520 |a Phase-contrast synchrotron X-ray microtomography (pcSyncX) based on the highly coherent X-ray beam has previously been used to visualize the microstructures of biologic specimens, but it has never been used to evaluate embolic debris adherent on a cerebral protection device (CPD). The purpose of this study was to demonstrate the feasibility of pcSyncX for evaluating embolic debris during carotid artery stenting (CAS). Five patients (four males, age range 67-77 years) with severe carotid artery stenosis underwent CAS. The retrieved CPD was exposed to synchrotron radiation and 1000 pcSyncX projection images were obtained by rotating the CPD through 180°. An X-ray shadow of a CPD was converted into a visual image by the scintillator. After microtomographic reconstruction, the three-dimensionally reconstructed images were further segmented into the embolic debris and CPD. The total volume of emboli was calculated by summing the volume at each scanning level. The number of membrane pores covered by emboli as seen from the outer surface was counted and the percentage of covered area was calculated. Embolic debris was clearly demonstrated not only on the inner surface and within pores but also on the outer surface of the CPD. The mean total volume of embolic debris was 0.538 × 10(-6) mm(3) (range 0.225-0.965 × 10(-6) mm(3)). Most (61.5%) of the debris was located at the apical one-third of the CPD and 20.8% of the pore area was covered by debris 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a carotid artery stenting 
650 4 |a cerebral protection device 
650 4 |a embolic debris 
650 4 |a microtomography 
650 4 |a phase contrast 
650 4 |a synchrotron X-rays 
700 1 |a Kim, Ho Kyun  |e verfasserin  |4 aut 
700 1 |a Kim, Hong Tae  |e verfasserin  |4 aut 
700 1 |a Han, Sung Mi  |e verfasserin  |4 aut 
700 1 |a Do, Jin Kuk  |e verfasserin  |4 aut 
700 1 |a Do, Young Rok  |e verfasserin  |4 aut 
700 1 |a Lee, Hui Joong  |e verfasserin  |4 aut 
700 1 |a Lee, Jongmin  |e verfasserin  |4 aut 
700 1 |a Lim, Jae Hong  |e verfasserin  |4 aut 
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