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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1107/S1600577513023771
|2 doi
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|a pubmed25n0779.xml
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|a (DE-627)NLM233924043
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|a (NLM)24365928
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Bazin, Dominique
|e verfasserin
|4 aut
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|a The status of strontium in biological apatites
|b an XANES/EXAFS investigation
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.08.2014
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|a Date Revised 24.12.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Osteoporosis represents a major public health problem through its association with fragility fractures. The public health burden of osteoporotic fractures will rise in future generations, due in part to an increase in life expectancy. Strontium-based drugs have been shown to increase bone mass in postmenopausal osteoporosis patients and to reduce fracture risk but the molecular mechanisms of the action of these Sr-based drugs are not totally elucidated. The local environment of Sr(2+) cations in biological apatites present in pathological and physiological calcifications in patients without such Sr-based drugs has been assessed. In this investigation, X-ray absorption spectra have been collected for 17 pathological and physiological calcifications. These experimental data have been combined with a set of numerical simulations using the ab initio FEFF9 X-ray spectroscopy program which takes into account possible distortion and Ca/Sr substitution in the environment of the Sr(2+) cations. For selected samples, Fourier transforms of the EXAFS modulations have been performed. The complete set of experimental data collected on 17 samples indicates that there is no relationship between the nature of the calcification (physiological and pathological) and the adsorption mode of Sr(2+) cations (simple adsorption or insertion). Such structural considerations have medical implications. Pathological and physiological calcifications correspond to two very different preparation procedures but are associated with the same localization of Sr(2+) versus apatite crystals. Based on this study, it seems that for supplementation of Sr at low concentration, Sr(2+) cations will be localized into the apatite network
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ca phosphate apatites
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|a Fourier transform infrared spectroscopy
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|a X-ray absorption spectroscopy
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|a pathological calcifications
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|a physiological calcifications
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|a strontium environment
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|a Apatites
|2 NLM
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|a Strontium
|2 NLM
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| 650 |
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|a YZS2RPE8LE
|2 NLM
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| 700 |
1 |
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|a Dessombz, Arnaud
|e verfasserin
|4 aut
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| 700 |
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|a Nguyen, Christelle
|e verfasserin
|4 aut
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| 700 |
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|a Ea, Hang Korng
|e verfasserin
|4 aut
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| 700 |
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|a Lioté, Frédéric
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rehr, John
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chappard, Christine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rouzière, Stephan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thiaudière, Dominique
|e verfasserin
|4 aut
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| 700 |
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|a Reguer, Solen
|e verfasserin
|4 aut
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| 700 |
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|a Daudon, Michel
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 21(2014), Pt 1 vom: 15. Jan., Seite 136-42
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
1 |
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|g volume:21
|g year:2014
|g number:Pt 1
|g day:15
|g month:01
|g pages:136-42
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|u http://dx.doi.org/10.1107/S1600577513023771
|3 Volltext
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|d 21
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|e Pt 1
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|c 01
|h 136-42
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