Acute ablation of DP thymocytes induces up-regulation of IL-22 and Foxn1 in TECs

Acute ablation of DP thymocytes induces up-regulation of IL-22 and Foxn1 in TECs

Copyright © 2013 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 150(2014), 1 vom: 15. Jan., Seite 101-8
1. Verfasser: Pan, Bin (VerfasserIn)
Weitere Verfasser: Liu, Jie, Zhang, Ying, Sun, Yuqi, Wu, Qingyun, Zhao, Kai, Zeng, Lingyu, Xu, Kailin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't DN DP Dex Foxn1 HCT SP TBI TEC mehr... Thymic epithelial cells; Thymus; dexamethasone double negative double positive hematopoietic cell transplantation single positive thymic epithelial cell. total body irradiation Forkhead Transcription Factors Interleukins Whn protein Dexamethasone 7S5I7G3JQL
Beschreibung
Zusammenfassung:Copyright © 2013 Elsevier Inc. All rights reserved.
Thymic epithelial cells (TECs) provide the basic architecture for the development of thymocytes. TEC is regenerative after impairment in thymus of young mice. However, how this regeneration program is governed remains unclear. Transcription factor Foxn1 is a central mediator of the differentiation and function of TEC. We examined the relation between thymic injury and Foxn1 in TEC. Total body irradiation (TBI) treatments induced up-regulation of Foxn1 in TEC, which was abolished when thymic function recovered. Specific depletion of double positive (DP) thymocytes triggered the up-regulation of Foxn1. On the other hand, extracellular IL-22 is a potential regulator of homeostasis of TEC. We demonstrated that TBI treatments also induced the up-regulation of intrathymic IL-22. Expression pattern of Foxn1 shares similar characteristics with IL-22. Furthermore, Foxn1 related genes that regulate the function of TEC were also up-regulated. Thus, our data reveal that TBI treatment triggers regeneration program of TEC
Beschreibung:Date Completed 11.03.2014
Date Revised 13.12.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.11.002