T-cell dependent immunogenicity of protein therapeutics Preclinical assessment and mitigation

T-cell dependent immunogenicity of protein therapeutics : Preclinical assessment and mitigation

© 2013. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 3 vom: 14. Dez., Seite 534-55
1. Verfasser: Jawa, Vibha (VerfasserIn)
Weitere Verfasser: Cousens, Leslie P, Awwad, Michel, Wakshull, Eric, Kropshofer, Harald, De Groot, Anne S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Review 50% inhibitory concentration ADA ALN APC CFSE Cell-mediated immunity ELISA ELISpot mehr... FPX FVIII HLA IC(50) IEDB Immune Epitope Database Analysis Resource Immunogenicity; MHC ORG PBMC Quality-by-Design; SFC T T cell receptor T cell; T-cell dependent, thymus dependent T-cell independent TCR Td Ti Treg aTreg adaptive regulatory T cells anti-drug antibodies antigen-presenting cells artificial lymph node carboxyfluorescein succinimidyl ester enzyme-linked immunosorbent assay enzyme-linked immunosorbent spot-forming factor VIII human leukocyte antigen iTreg induced regulatory T cells major histocompatibility complex nTregs natural regulatory T cells peripheral blood mononuclear cells recombinant Fc fusion protein regulatory T cells spot-forming cells thymus unmodified original epitopes Antibodies, Monoclonal Biological Products Biomarkers, Pharmacological Cytokines Intercellular Signaling Peptides and Proteins Recombinant Proteins
Online verfügbar Volltext