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20250216064130.0 |
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cr uuu---uuuuu |
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231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2013.09.005
|2 doi
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| 028 |
5 |
2 |
|a pubmed25n0775.xml
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|a (DE-627)NLM232723621
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|a (NLM)24239756
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|a (PII)S1521-6616(13)00242-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Hong, Heather A
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a KIR2DS4 allelic variants
|b Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission
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| 264 |
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1 |
|c 2013
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.12.2013
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| 500 |
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|a Date Revised 03.12.2013
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a © 2013.
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| 520 |
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|a KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants [intrapartum (IP), in utero (IU) or IU2 (an IU-enriched infected group)]. The frequency of KIR2DS4-v was significantly higher in IU2 infants compared to EU infants (P=0.022, OR=2.88); this association was more significant amongst AA haplotypes (P=0.004, OR=18.4). Possession of KIR2DS4-f in the mother with absence in the infant (M+I- discordance) was associated with a higher risk of IP transmission (P=0.005, OR=3.84); whilst in M-I+ discordance, infant possession of KIR2DS4-v was associated with increased risk of IU acquisition (P=0.002; OR=6.40). This study highlights the importance of KIR2DS4 in HIV-1 transmission/acquisition
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a HLA-C ligands;
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| 650 |
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4 |
|a Killer cell immunoglobulin-like receptors (KIRs);
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| 650 |
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4 |
|a Mother-to-child-transmission (MTCT)
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| 650 |
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4 |
|a NK function;
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| 650 |
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4 |
|a Natural killer (NK) cells;
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| 650 |
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7 |
|a KIR2DS4 protein, human
|2 NLM
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| 650 |
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7 |
|a Protein Isoforms
|2 NLM
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| 650 |
|
7 |
|a Receptors, KIR
|2 NLM
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| 700 |
1 |
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|a Paximadis, Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gray, Glenda E
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Kuhn, Louise
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Tiemessen, Caroline T
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 149(2013), 3 vom: 22. Dez., Seite 498-508
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:149
|g year:2013
|g number:3
|g day:22
|g month:12
|g pages:498-508
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2013.09.005
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
|
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
|
| 951 |
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|a AR
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| 952 |
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|d 149
|j 2013
|e 3
|b 22
|c 12
|h 498-508
|