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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.08.011
|2 doi
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|a pubmed25n0774.xml
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|a (DE-627)NLM232468354
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|a (NLM)24211716
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|a (PII)S1521-6616(13)00233-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Bemark, Mats
|e verfasserin
|4 aut
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|a A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27⁻IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.12.2013
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2013 Elsevier Inc. All rights reserved.
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|a The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27(+) B cells formed after transplantation with the number of CD27(+)IgM(high) cells more affected than class-switched ones. A previously unacknowledged population of CD27(-)IgM(high) cells made up the majority of B cells and this population was also enlarged in healthy children compared to adults. Only a minority of these CD27(-)IgM(high) B cells expressed markers typical for transitional B cells, and the non-transitional CD27(-)IgM(high) cells could be further divided into subpopulations based on their ability to extrude the dye Rhodamine 123 and their expression of CD45RB(MEM55), a glycosylation-dependent epitope. Thus, we define several novel human CD27(-)IgM(high) B cell subpopulations in blood, all of which are present in higher frequencies and numbers in young children and after HSCT than in adults
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a B cell
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|a Hematopoietic stem cell transplantation
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|a Immunological ontogeny
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|a Lymphocyte development
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|a Epitopes, B-Lymphocyte
|2 NLM
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|a Fluorescent Dyes
|2 NLM
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|a Immunoglobulin M
|2 NLM
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|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 650 |
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|a Rhodamine 123
|2 NLM
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| 650 |
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|a 1N3CZ14C5O
|2 NLM
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| 650 |
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|a Leukocyte Common Antigens
|2 NLM
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| 650 |
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|a EC 3.1.3.48
|2 NLM
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| 700 |
1 |
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|a Friskopp, Linda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saghafian-Hedengren, Shanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Koethe, Susanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fasth, Anders
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abrahamsson, Jonas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sverremark-Ekström, Eva
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andersson, Bengt A
|e verfasserin
|4 aut
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| 700 |
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|a Mellgren, Karin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 149(2013), 3 vom: 28. Dez., Seite 421-31
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:149
|g year:2013
|g number:3
|g day:28
|g month:12
|g pages:421-31
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|u http://dx.doi.org/10.1016/j.clim.2013.08.011
|3 Volltext
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