Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 3 vom: 28. Dez., Seite 411-20
1. Verfasser:	Li, Dapeng (VerfasserIn)
Weitere Verfasser:	Cai, Wenqian, Gu, Runxia, Zhang, Yi, Zhang, Huafeng, Tang, Ke, Xu, Pingwei, Katirai, Foad, Shi, Wei, Wang, Longqiang, Huang, Tao, Huang, Bo
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2013
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Autoimmune thyroiditis Hashimoto's thyroiditis IL-17 Iodine Regulatory T cell Th17 cell Interleukin-17 9679TC07X4

Beschreibung
Zusammenfassung:	© 2013. Published by Elsevier Inc. All rights reserved. Hashimoto's thyroiditis (HT) has long been epidemiologically associated with excess iodine levels. However, the underlying immunological mechanisms still remain largely unexplored. Th17 cells are commonly recognized as playing vital roles in various autoimmune diseases. Here we show that intra-thyroid infiltrating Th17 cells and serum IL-17 levels were significantly increased in HT patients. However, the concentration of serum IL-17 was inversely correlated with patients' residual thyroid function while the heterogeneously expressed thyroid IL-17 was directly correlated with local fibrosis. Administration of moderate high levels of iodine was found to facilitate the polarization of murine splenic naïve T cells into Th17 cells, whereas extreme high levels of iodine favored Th1 polarization and inhibited Treg development. These findings suggest that both Th1 and Th17 cells may be involved in the pathogenesis of HT and high levels of iodine may play a critical role in this process by modulating T cell differentiation
Beschreibung:	Date Completed 30.12.2013 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2013.10.001