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20231224093041.0 |
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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.08.005
|2 doi
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|a pubmed24n0775.xml
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|a (DE-627)NLM232468338
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|a (NLM)24211713
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|a (PII)S1521-6616(13)00218-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Luu, Van Phi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a TSPAN33 is a novel marker of activated and malignant B cells
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|c 2013
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.12.2013
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2013.
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|a We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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4 |
|a B cell maturation antigen
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| 650 |
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|a B cells
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| 650 |
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|a BCMA
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4 |
|a BIGE
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| 650 |
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4 |
|a BL
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| 650 |
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4 |
|a Biomarker
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| 650 |
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4 |
|a Burkitt's lymphoma
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| 650 |
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4 |
|a DLBCL
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| 650 |
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4 |
|a Diffuse large B cell lymphoma
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| 650 |
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4 |
|a HL
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| 650 |
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4 |
|a Hodgkin's lymphoma
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| 650 |
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4 |
|a Lupus erythematosus
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| 650 |
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4 |
|a Lymphoma
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| 650 |
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4 |
|a NHL
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| 650 |
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4 |
|a RA
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| 650 |
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4 |
|a Rheumatoid arthritis
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| 650 |
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4 |
|a SLE
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| 650 |
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4 |
|a TSPAN33
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| 650 |
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4 |
|a Tetraspanin 33
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| 650 |
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4 |
|a body index of gene expression (database)
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| 650 |
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4 |
|a non-Hodgkin's lymphoma
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| 650 |
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4 |
|a rheumatoid arthritis
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| 650 |
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4 |
|a systemic lupus erythematosus
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| 650 |
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4 |
|a tetraspanin 33
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| 650 |
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7 |
|a Biomarkers
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharides
|2 NLM
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| 650 |
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7 |
|a TSPAN33 protein, human
|2 NLM
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| 650 |
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7 |
|a Tetraspanins
|2 NLM
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| 650 |
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7 |
|a Tetradecanoylphorbol Acetate
|2 NLM
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| 650 |
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7 |
|a NI40JAQ945
|2 NLM
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| 700 |
1 |
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|a Hevezi, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vences-Catalan, Felipe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maravillas-Montero, José Luis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a White, Clayton Alexander
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Casali, Paolo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Llorente, Luis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jakez-Ocampo, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lima, Guadalupe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vilches-Cisneros, Natalia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Flores-Gutiérrez, Juan Pablo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Santos-Argumedo, Leopoldo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zlotnik, Albert
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 149(2013), 3 vom: 28. Dez., Seite 388-99
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:149
|g year:2013
|g number:3
|g day:28
|g month:12
|g pages:388-99
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2013.08.005
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 149
|j 2013
|e 3
|b 28
|c 12
|h 388-99
|