Regulatory and effector T-cells are differentially modulated by Dexamethasone

Regulatory and effector T-cells are differentially modulated by Dexamethasone

© 2013.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 3 vom: 28. Dez., Seite 400-10
1. Verfasser: Pandolfi, Julieta (VerfasserIn)
Weitere Verfasser: Baz, Plácida, Fernández, Pablo, Discianni Lupi, Ailén, Payaslián, Florencia, Billordo, Luis Ariel, Fainboim, Leonardo, Arruvito, Lourdes
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't APCs Apoptosis Cytokines Dex Dexamethasone Effector T cells GC GR mehr... Glucocorticoids Regulatory T cells Teff Tregs aTregs activated Tregs antigen presenting cells effector T cells geoMFI geometric mean fluorescence intensity glucocorticoid receptor glucocorticoids rTregs regulatory T cells resting Tregs Anti-Inflammatory Agents FOXP3 protein, human Forkhead Transcription Factors IL2RA protein, human Interleukin-2 Interleukin-2 Receptor alpha Subunit 7S5I7G3JQL
Beschreibung
Zusammenfassung:© 2013.
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response, but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all FOXP3+CD4+ T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs either, our results support the notion that under Dex treatment, the regulatory T-cell compartment maintains its homeostasis
Beschreibung:Date Completed 30.12.2013
Date Revised 03.12.2013
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.09.008