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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4029
|2 doi
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|a pubmed24n0774.xml
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|a eng
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| 100 |
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|a Staško, Andrej
|e verfasserin
|4 aut
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|a Oxidation of quinolones with peracids (an in situ EPR study)
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 07.08.2014
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|a Date Revised 18.12.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 John Wiley & Sons, Ltd.
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|a 4-Oxoquinoline derivatives (quinolones) represent heterocyclic compounds with a variety of biological activities, along with interesting chemical reactivity. The quinolone derivatives possessing secondary amino hydrogen at the nitrogen of the enaminone system are oxidized with 3-chloroperbenzoic acid to nitroxide radicals in the primary step while maintaining their 4-pyridone ring. Otherwise, N-methyl substituted quinolones also form nitroxide radicals coupled with the opening of the 4-pyridone ring in a gradual oxidation of the methyl group via the nitrone-nitroxide spin-adduct cycle. This was confirmed in an analogous oxidation using N,N-dimethylaniline as a model compound. N-Ethyl quinolones in contrast to its N-methyl analog form only one nitroxide radical without a further degradation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a EPR spectroscopy
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|a N,N-dimethylaniline
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|a nitroxide
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|a oxidation
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|a peracids
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|a quinolones
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|a Aniline Compounds
|2 NLM
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|a Chlorobenzoates
|2 NLM
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|a Quinolones
|2 NLM
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|a 3-chlorobenzoic acid
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|a 02UOJ7064K
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|a dimethylaniline N-oxide
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|a Oxygen
|2 NLM
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|a S88TT14065
|2 NLM
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|a Milata, Viktor
|e verfasserin
|4 aut
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|a Barbieriková, Zuzana
|e verfasserin
|4 aut
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|a Brezová, Vlasta
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 52(2014), 1-2 vom: 21. Jan., Seite 22-6
|w (DE-627)NLM098179667
|x 1097-458X
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|g volume:52
|g year:2014
|g number:1-2
|g day:21
|g month:01
|g pages:22-6
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|u http://dx.doi.org/10.1002/mrc.4029
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