High-resolution crystal structure of Streptococcus pyogenes β-NAD⁺ glycohydrolase in complex with its endogenous inhibitor IFS reveals a highly water-rich interface
One of the virulence factors produced by Streptococcus pyogenes is β-NAD(+) glycohydrolase (SPN). S. pyogenes injects SPN into the cytosol of an infected host cell using the cytolysin-mediated translocation pathway. As SPN is toxic to bacterial cells themselves, S. pyogenes possesses the ifs gene th...
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Bibliographische Detailangaben
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 20(2013), Pt 6 vom: 07. Nov., Seite 962-7
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| 1. Verfasser: |
Yoon, Ji Young
(VerfasserIn) |
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| Weitere Verfasser: |
An, Doo Ri,
Yoon, Hye Jin,
Kim, Hyoun Sook,
Lee, Sang Jae,
Im, Ha Na,
Jang, Jun Young,
Suh, Se Won |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2013
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
ADP-ribosyltransferase
ARTT loop
IFS
Streptococcus pyogenes
β-NAD+ glycohydrolase
Enzyme Inhibitors
Recombinant Proteins
Water
mehr...
059QF0KO0R
NAD+ Nucleosidase
EC 3.2.2.5 |
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