Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor
The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 Å resolution. The X-ray crystallographic study shows that the benzimidazole inhibitor forms a non-covalent interaction with the catalytic domain of human chymase. The hydrophobic frag...
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Bibliographische Detailangaben
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 20(2013), Pt 6 vom: 07. Nov., Seite 914-8
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| 1. Verfasser: |
Matsumoto, Yoshiyuki
(VerfasserIn) |
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| Weitere Verfasser: |
Kakuda, Shinji,
Koizumi, Masahiro,
Mizuno, Tsuyoshi,
Muroga, Yumiko,
Kawamura, Takashi,
Takimoto-Kamimura, Midori |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2013
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation
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| Schlagworte: | Journal Article
FMO calculation
benzimidazole
chymase inhibitor
crystal structure
Benzimidazoles
Chymases
EC 3.4.21.39 |
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