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231224s2013 xx ||||| 00| ||chi c |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
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|a Huang, Hui-zhi
|e verfasserin
|4 aut
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|a Human umbilical cord blood mononuclear cell transplantation promotes long-term neurobehavioral functional development of newborn SD rats with hypoxic ischemic brain injury
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 10.03.2014
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|a Date Revised 10.12.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To explore the effect of human umbilical cord blood mononuclear cells (UCBMC) promoting nerve behavior function and brain tissue recovery of neonatal SD rat with hypoxic ischemic brain injury (HIBI)
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|a METHOD: A modified newborn rat model that had a combined hypoxic and ischemic brain injury as described by Rice-Vannucci was used, early nervous reflex, the Morris water maze and walking track analysis were used to evaluate nervous behavioral function, and brain MRI, HE staining to evaluate brain damage recovery
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|a RESULT: Newborn rat Rice-Vannucci model showed significant brain atrophy, obvious hemiplegia of contralateral limbs,e.g right step length [(7.67 ± 0.46) cm vs. (8.22 ± 0.50) cm, F = 1.494] and toe distance [(0.93 ± 0.06) cm vs. (1.12 ± 0.55) cm, F = 0.186] were significantly reduced compared with left side, learning and memory ability was significantly impaired compared with normal control group (P < 0.01); Cliff aversion [(8.44 ± 2.38) s vs.(14.22 ± 5.07) s, t = 4.618] and negative geotaxis reflex time [(7.26 ± 2.00) s vs. (11.76 ± 3.73) s, t = 4.755] on postnatal 14 days of HIBI+ transplantation group were significantly reduced compared with HIBI+NaCl group (P < 0.01) ; the Morris water maze experiment showed escape latency [ (23.11 ± 6.64) s vs. (34.04 ± 12.95) s, t = 3.356] and swimming distance [ (9.12 ± 1.21) cm vs.(12.70 ± 1.53) cm, t = 17.095] of HIBI+transplantation group were significantly reduced compared with those of HIBI+NaCl group (P < 0.01) ; the residual brain volume on postnatal 10 d [ (75.37 ± 4.53)% vs. (67.17 ± 4.08)%, t = -6.017] and 67 d [ (69.05 ± 3.58)% vs.(60.83 ± 3.69)%, t = -7.148]of HIBI+ transplantation group were significantly larger than those of HIBI+NaCl group (P < 0.01); After human UCBMC transplantation, left cortical edema significantly reduced and nerve cell necrosis of HIBI+ transplantation group is not obvious compared with HIBI+NaCl group
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|a CONCLUSION: Human UCBMC intraperitoneal transplantation significantly promoted recovery of injured brain cells and neurobehavioral function development
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Wen, Xiao-hong
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Hui
|e verfasserin
|4 aut
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| 700 |
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|a Huang, Jin-hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Shang-quan
|e verfasserin
|4 aut
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| 700 |
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|a Ren, Wei-hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fang, Wen-xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qian, Yin-feng
|e verfasserin
|4 aut
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| 700 |
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|a Hou, Wei-zhu
|e verfasserin
|4 aut
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| 700 |
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|a Yan, Ming-jie
|e verfasserin
|4 aut
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| 700 |
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|a Yao, You-heng
|e verfasserin
|4 aut
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| 700 |
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|a Li, Wei-Zu
|e verfasserin
|4 aut
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| 700 |
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|a Li, Qian-Jin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 51(2013), 6 vom: 30. Juni, Seite 460-6
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
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|g volume:51
|g year:2013
|g number:6
|g day:30
|g month:06
|g pages:460-6
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|d 51
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