Protective effect of cotransfection of A20 and HO-1 gene against the apoptosis induced by TNF-α in rat islets in vitro

OBJECTIVE: To establish the method for cotransferring human A20 gene and human heme oxygenase-1 (HO-1) gene into the isolated rat islets using lentiviral transfection system, and to study the protective effect of A20 and HO-1 protein against the apoptosis induced by cycloheximide (CHX) and TNF-α, an...

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Publié dans:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 51(2013), 6 vom: 30. Juni, Seite 420-5
Auteur principal: Lu, Zhong (Auteur)
Autres auteurs: Shen, Shui-xian, Zhi, Di-jing, Xu, Hong, Guo, Li-he, Luo, Fei-hong
Format: Article
Langue:Chinese
Publié: 2013
Accès à la collection:Zhonghua er ke za zhi = Chinese journal of pediatrics
Sujets:Journal Article Research Support, Non-U.S. Gov't DNA-Binding Proteins Insulin Intracellular Signaling Peptides and Proteins Nuclear Proteins Tumor Necrosis Factor-alpha HMOX1 protein, human EC 1.14.14.18 Heme Oxygenase-1 plus... TNFAIP3 protein, human EC 3.4.19.12 Tumor Necrosis Factor alpha-Induced Protein 3 Caspase 3 EC 3.4.22.-