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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la402229k
|2 doi
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|a pubmed24n0770.xml
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|a eng
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|a Redolfi Riva, Eugenio
|e verfasserin
|4 aut
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| 245 |
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|a PMMA/polysaccharides nanofilm loaded with adenosine deaminase inhibitor for targeted anti-inflammatory drug delivery
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 21.05.2014
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|a Date Revised 29.10.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A novel drug delivery vector, a free-standing polymeric ultrathin film (nanofilm) composed of PMMA and a polysaccharides multilayer, is presented. Chitosan and sodium alginate are alternatively deposited by spin-assisted LbL assembly onto a plasma-treated PMMA thin film. Hydrophobic anti-inflammatory drugs, an adenosine deaminase inhibitor (APP) and its fluorescent dansyl derivate (APP-Dns), are encapsulated inside the LbL multilayer using a simple casting deposition procedure. The resulting drug loaded nanofilm can be suspended in water upon dissolution of a PVA sacrificial layer. Morphological characterization of the nanofilm shows that PMMA/LbL nanofilms possess nanometric thickness (<200 nm) and very low surface roughness (1-2 nm for drug loaded nanofilms and <1 nm for blank nanofilm). Drug loaded films exhibit a diffusion controlled release mechanism following the Korsmayer-Peppas release model, confirmed by the fit of release data with a characteristic power law. Drug release is impaired through the PMMA layer, which acts effectively as a barrier for drug transport. This ultrathin polymer film can find application as a nanopatch for targeted inflammatory drug delivery to treat localized pathologies as inflammatory bowel disease
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|a Journal Article
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|a Adenosine Deaminase Inhibitors
|2 NLM
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|a Anti-Inflammatory Agents, Non-Steroidal
|2 NLM
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|a Drug Carriers
|2 NLM
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|a Polysaccharides
|2 NLM
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|a Polymethyl Methacrylate
|2 NLM
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|a 9011-14-7
|2 NLM
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|a Desii, Andrea
|e verfasserin
|4 aut
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|a Sartini, Stefania
|e verfasserin
|4 aut
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|a La Motta, Concettina
|e verfasserin
|4 aut
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|a Mazzolai, Barbara
|e verfasserin
|4 aut
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|a Mattoli, Virgilio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 43 vom: 29. Okt., Seite 13190-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:29
|g year:2013
|g number:43
|g day:29
|g month:10
|g pages:13190-7
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|u http://dx.doi.org/10.1021/la402229k
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