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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la402826f
|2 doi
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|a pubmed24n0769.xml
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|a (DE-627)NLM230796540
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|a (NLM)24028496
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Schmidtke, Christian
|e verfasserin
|4 aut
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| 245 |
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|a Glycoconjugated amphiphilic polymers via click-chemistry for the encapsulation of quantum dots
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.05.2014
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|a Date Revised 09.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Herein, we present a strategy for the glycoconjugation of nanoparticles (NPs), with a special focus on fluorescent quantum dots (QDs), recently described by us as "preassembly" approach. Therein, prior to the encapsulation of diverse nanoparticles by an amphiphilic poly(isoprene)-b-poly(ethylene glycol) diblock copolymer (PI-b-PEG), the terminal PEG appendage was modified by covalently attaching a carbohydrate moiety using Huisgen-type click-chemistry. Successful functionalization was proven by NMR spectroscopy. The terminally glycoconjugated polymers were subsequently used for the encapsulation of QDs in a phase transfer process, which fully preserved fluorescence properties. Binding of these nanoconstructs to the lectin Concanavalin A (Con A) was studied via surface plasmon resonance (SPR). Depending on the carbohydrate moiety, namely, D-manno-heptulose, D-glucose, D-galactose, 2-deoxy-2-{[methylamino)carbonyl]amino}-D-glucopyranose ("des(nitroso)-streptozotocin"), or D-maltose, the glycoconjugated QDs showed enhanced affinity constants due to multivalent binding effects. None of the constructs showed toxicity from 0.001 to 1 μM (particle concentration) using standard WST and LDH assays on A549 cells
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Polymers
|2 NLM
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|a Concanavalin A
|2 NLM
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|a 11028-71-0
|2 NLM
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|a Kreuziger, Anna-Marlena
|e verfasserin
|4 aut
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|a Alpers, Dirk
|e verfasserin
|4 aut
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|a Jacobsen, Anna
|e verfasserin
|4 aut
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|a Leshch, Yevgeniy
|e verfasserin
|4 aut
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|a Eggers, Robin
|e verfasserin
|4 aut
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|a Kloust, Hauke
|e verfasserin
|4 aut
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|a Tran, Huong
|e verfasserin
|4 aut
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|a Ostermann, Johannes
|e verfasserin
|4 aut
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|a Schotten, Theo
|e verfasserin
|4 aut
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|a Thiem, Joachim
|e verfasserin
|4 aut
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|a Thimm, Julian
|e verfasserin
|4 aut
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| 700 |
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|a Weller, Horst
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 40 vom: 08. Okt., Seite 12593-600
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:29
|g year:2013
|g number:40
|g day:08
|g month:10
|g pages:12593-600
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|u http://dx.doi.org/10.1021/la402826f
|3 Volltext
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