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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-013-1120-7
|2 doi
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|a pubmed25n0769.xml
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|a (DE-627)NLM230777872
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|a (NLM)24026525
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ishiniwa, Hiroko
|e verfasserin
|4 aut
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|a Dioxin pollution disrupts reproduction in male Japanese field mice
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.05.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Dioxins cause various adverse effects in animals including teratogenesis, induction of drug metabolizing enzymes, tumor promotion, and endocrine disruption. Above all, endocrine disruption is known to disturb reproduction in adult animals and may, also seriously impact their offspring. However, most previous studies have quantified the species-specific accumulation of dioxins, whereas few studies have addressed the physiological impacts of dioxins on wildlife, such as reduced reproductive function. Here we clarify an effect of endocrine disruption caused by dioxins on the Japanese field mouse, Apodemus speciosus. Japanese field mice collected from various sites polluted with dioxins accumulated high concentrations of dioxins in their livers. Some dioxin congeners, especially, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin, 3,3',4,4',5-pentachloro biphenyl, 1,2,3,4,6,7,8-heptachlorodibenzofuran, and octachlorodibenzo-p-dioxin, which showed high biota-soil accumulation factors, contributed to concentration of dioxins in mouse livers with an increase of accumulation of total dioxins. As for physiological effects on the Japanese field mouse, high levels of cytochrome P450 1A1 (CYP1A1) mRNA, a drug metabolizing enzyme induced by dioxins, were found in the livers of mice captured at polluted sites. Furthermore, at such sites polluted with dioxins, increased CYP1A1 expression coincided with reduced numbers of active spermatozoa in mice. Thus, disruption in gametogenesis observed in these mice suggests that dioxins not only negatively impact reproduction among Japanese field mice, but might also act as a kind of selection pressure in a chemically polluted environment
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Dioxins
|2 NLM
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|a Soil
|2 NLM
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|a Soil Pollutants
|2 NLM
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|a Cytochrome P-450 CYP1A1
|2 NLM
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| 650 |
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|a EC 1.14.14.1
|2 NLM
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| 700 |
1 |
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|a Sakai, Mizuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tohma, Shimon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsuki, Hidenori
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Takahashi, Yukio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kajiwara, Hideo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sekijima, Tsuneo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1998
|g 22(2013), 9 vom: 12. Nov., Seite 1335-47
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:22
|g year:2013
|g number:9
|g day:12
|g month:11
|g pages:1335-47
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|u http://dx.doi.org/10.1007/s10646-013-1120-7
|3 Volltext
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