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20231224085038.0 |
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231224s2013 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.201302952
|2 doi
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|a pubmed24n0769.xml
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|a (DE-627)NLM230706800
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|a (NLM)24018824
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ng, Victor Wee Lin
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Synergistic co-delivery of membrane-disrupting polymers with commercial antibiotics against highly opportunistic bacteria
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 14.07.2014
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a A series of vitamin E-containing biodegradable antimicrobial cationic polycarbonates is designed and synthesized via controlled organocatalytic ring-opening polymerization. The incorporation of vitamin E significantly enhances antimicrobial activity. These polymers demonstrate broad-spectrum antimicrobial activity against various microbes, e.g., S. aureus (Gram-positive), E-coli (Gram-negative) and C. albicans (fungi). More importantly, the co-delivery of such polymers with selected antibiotics (e.g., doxycycline) shows high synergism towards difficult-to-kill bacteria P. aeruginosa. These findings suggest that these vitamin E-functionalized polycarbonates are potentially useful antimicrobial agents against challenging bacterial/fungal infections
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a antibiotics
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|a antimicrobial
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|a biodegradable and biocompatible polycarbonates
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|a co-delivery
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|a vitamin E
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|a Anti-Infective Agents
|2 NLM
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| 650 |
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|a Polycarboxylate Cement
|2 NLM
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| 650 |
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|a Vitamin E
|2 NLM
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| 650 |
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|a 1406-18-4
|2 NLM
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| 650 |
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|a polycarbonate
|2 NLM
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| 650 |
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|a 25766-59-0
|2 NLM
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| 650 |
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7 |
|a Doxycycline
|2 NLM
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| 650 |
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7 |
|a N12000U13O
|2 NLM
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| 700 |
1 |
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|a Ke, Xiyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Ashlynn L Z
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hedrick, James L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Yi Yan
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 25(2013), 46 vom: 10. Dez., Seite 6730-6
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:25
|g year:2013
|g number:46
|g day:10
|g month:12
|g pages:6730-6
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|u http://dx.doi.org/10.1002/adma.201302952
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