Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 41 vom: 06. Nov., Seite 5928-36
1. Verfasser: Xu, Ligeng (VerfasserIn)
Weitere Verfasser: Liu, Ye, Chen, Zhiyun, Li, Wei, Liu, Ying, Wang, Liming, Ma, Liying, Shao, Yiming, Zhao, Yuliang, Chen, Chunying
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't HIV-1 fullerenol nano-adjuvant vaccine virus-like particle AIDS Vaccines Adjuvants, Immunologic Fullerenes mehr... Vaccines, DNA Vaccines, Virus-Like Particle 182024-42-6
Beschreibung
Zusammenfassung:© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM -biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways
Beschreibung:Date Completed 06.10.2014
Date Revised 11.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201300583