Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension

Blockade of the serotonin reuptake transporter (5-HTT), using fluoxetine, has been identified as a potential therapeutic target for preventing and, importantly, reversing pulmonary hypertension (PH). This study utilized synchrotron radiation microangiography to determine whether fluoxetine could pre...

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Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 20(2013), Pt 5 vom: 15. Sept., Seite 756-64
1. Verfasser: Gray, Emily A (VerfasserIn)
Weitere Verfasser: Tsuchimochi, Hirotsugu, Pearson, James T, Sonobe, Takashi, Fujii, Yutaka, Yoshimoto, Misa, Umetani, Keiji, Shirai, Mikiyasu, Schwenke, Daryl O
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article endothelial dysfunction fluoxetine monocrotaline pulmonary hypertension rarefaction rat serotonin Serotonin Plasma Membrane Transport Proteins Slc6a4 protein, rat mehr... Fluoxetine 01K63SUP8D Serotonin 333DO1RDJY Monocrotaline 73077K8HYV Acetylcholine N9YNS0M02X