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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201302363
|2 doi
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|a pubmed24n0765.xml
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|a (DE-627)NLM229727603
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|a (NLM)23913796
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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1 |
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|a Chien, Chih-Te
|e verfasserin
|4 aut
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|a Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 21.04.2014
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a We report on caged Pt nanoclusters that are able to exert tumor-inside activation for anticancer chemotherapeutics and to minimize systemic toxicity. By shrinking the Pt size to 1 nm, it possesses corrodibility for dissolution in weakly acidic organelles to release toxic Pt ions. The therapeutic effect in exerting tumor-inside activation is confirmed in vivo by post-modifying a pH-cleavable PEG corona and mixing it with a tumor-homing peptide for tumour suppression
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a cancer therapy
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|a corrodibility
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|a dendrimers
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|a platinum nanoclusters
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|a tumor-inside activation
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|a Antineoplastic Agents
|2 NLM
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|a Dendrimers
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|a Drug Carriers
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|a Platinum
|2 NLM
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|a 49DFR088MY
|2 NLM
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|a Carboplatin
|2 NLM
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|a BG3F62OND5
|2 NLM
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|a Cisplatin
|2 NLM
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|a Q20Q21Q62J
|2 NLM
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| 700 |
1 |
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|a Yan, Jia-Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chiu, Wan-Ching
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Te-Haw
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Chia-Yeh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Shu-Yi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 25(2013), 36 vom: 25. Sept., Seite 5067-73
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:25
|g year:2013
|g number:36
|g day:25
|g month:09
|g pages:5067-73
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|u http://dx.doi.org/10.1002/adma.201302363
|3 Volltext
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