Early axonal damage and progressive myelin pathology define the kinetics of CNS histopathology in a mouse model of multiple sclerosis

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 1 vom: 01. Okt., Seite 32-45
1. Verfasser:	Recks, Mascha S (VerfasserIn)
Weitere Verfasser:	Stormanns, Eva R, Bader, Jonas, Arnhold, Stefan, Addicks, Klaus, Kuerten, Stefanie
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2013
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't 4% paraformaldehyde/4% glutaraldehyde Axonal pathology; B6 C57BL/6 CFA CNS CST DC mehr... EAE EAE; Electron microscopy; FGF IFA MBP MBP-PLP fusion protein MOG MOG:35–55; MP4 MS NAWM NNND Neurodegeneration; OPC PFA-GA PLP VLC central nervous system complete Freund's adjuvant corticospinal tract dorsal column experimental autoimmune encephalomyelitis fibroblast growth factor incomplete Freund's adjuvant multiple sclerosis myelin basic protein myelin oligodendrocyte glycoprotein nearest neighbor neurofilament distance normal-appearing white matter oligodendrocyte precursor cells proteolipid protein ventrolateral column MP4 protein, chimeric Myelin Basic Protein Myelin Proteolipid Protein Myelin-Oligodendrocyte Glycoprotein Peptide Fragments Recombinant Fusion Proteins myelin oligodendrocyte glycoprotein (35-55) myelin proteolipid protein (178-191) 172228-98-7

Beschreibung
Zusammenfassung:	Copyright © 2013 Elsevier Inc. All rights reserved. Studies of MS histopathology are largely dependent on suitable animal models. While light microscopic analysis gives an overview of tissue pathology, it falls short in evaluating detailed changes in nerve fiber morphology. The ultrastructural data presented here and obtained from studies of myelin oligodendrocyte glycoprotein (MOG):35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice delineate that axonal damage and myelin pathology follow different kinetics in the disease course. While myelin pathology accumulated with disease progression, axonal damage coincided with the initial clinical disease symptoms and remained stable over time. This pattern applied both to irreversible axolysis and early axonal pathology. Notably, these histopathological patterns were reflected by the normal-appearing white matter (NAWM), suggesting that the NAWM is also in an active neurodegenerative state. The data underline the need for neuroprotection in MS and suggest the MOG model as a highly valuable tool for the assessment of different therapeutic strategies
Beschreibung:	Date Completed 12.11.2013 Date Revised 17.09.2013 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2013.06.004