Treatment of inflammatory bowel disease by chemokine receptor-targeted leukapheresis

Treatment of inflammatory bowel disease by chemokine receptor-targeted leukapheresis

Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 1 vom: 23. Okt., Seite 73-82
1. Verfasser: Eberhardson, Michael (VerfasserIn)
Weitere Verfasser: Marits, Per, Jones, Martina, Jones, Petra, Karlen, Per, Karlsson, Mats, Cotton, Graham, Woznica, Kerry, Maltman, Beatrice, Glise, Hans, Winqvist, Ola
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Clinical Trial Journal Article Research Support, Non-U.S. Gov't Apheresis CCL25 CCR9 Chemokines Inflammatory bowel disease Leukapheresis CC chemokine receptor 9 mehr... CCL25 protein, human Chemokines, CC Cytokines Receptors, CCR
Beschreibung
Zusammenfassung:Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Leukapheresis removes circulating leukocytes en route to the target organ. Hitherto unspecific matrixes have been used to remove leukocytes in inflammatory bowel disease (IBD). This report describes a novel selective leukapheresis column based on chemokine-chemokine receptor interaction. We found an increased expression of the gut homing chemokine receptor CCR9 on CD14(+) monocytes and on CD3(+) T lymphocytes from IBD patients. Biologically active CCL25 was coupled to a Sepharose matrix and demonstrated to selectively remove CCR9-expressing cells leaving other cell populations largely unaffected. A patient with active ulcerative colitis, was subjected to CCL25-column leukapheresis. Four days after treatment, he experienced clinical improvement and stable disease improvement ensued. The study illustrates that specific cells can be targeted using high affinity interactions, i.e., CCL25-CCR9 interactions to remove pathogenic gut-homing cells. Leukapheresis using the bCCL25 column should be investigated in a clinical phase I trial of patients with inflammatory bowel disease
Beschreibung:Date Completed 12.11.2013
Date Revised 17.09.2013
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.05.021