Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis

Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis

Copyright © 2013 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 1 vom: 08. Okt., Seite 46-54
1. Verfasser: Wang, YaoYao (VerfasserIn)
Weitere Verfasser: Yang, Yan, Luo, YangYang, Yin, YongXin, Wang, Qing, Li, YaPing, Kanekura, Takuro, Wang, JiuCun, Liang, GongPing, Zhao, Ming, Lu, QianJin, Xiao, Rong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Acetylation B cells Histone modification Methylation Systemic sclerosis Histones RNA, Messenger Jumonji Domain-Containing Histone Demethylases mehr... EC 1.14.11.- Histone-Lysine N-Methyltransferase EC 2.1.1.43 SUV39H2 protein, human HDAC2 protein, human EC 3.5.1.98 HDAC7 protein, human Histone Deacetylase 2 Histone Deacetylases
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100 1 |a Wang, YaoYao  |e verfasserin  |4 aut 
245 1 0 |a Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis 
264 1 |c 2013 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
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500 |a Date Completed 12.11.2013 
500 |a Date Revised 09.04.2022 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2013 Elsevier Inc. All rights reserved. 
520 |a OBJECTIVES: To investigate alterations in histone modifications in B cells and their role in the pathogenesis of systemic sclerosis (SSc) 
520 |a METHODS: Global histone H3/H4 acetylation and H3K4/H3K9 methylation in B cells of SSc were tested by EpiQuik™ assay kits. Related histone modifier enzymes were measured by RT-PCR and Western blot 
520 |a RESULTS: Global histone H4 hyperacetylation and global histone H3K9 hypomethylation were observed in SSc B cells compared with controls. Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and, SUV39H2 were significantly down-regulated in SSc B cells relative to controls. Global histone H4 acetylation and the expression of HDAC2 were negatively correlated. Global histone H3K9 methylation and the expression of SUV39H2 protein were positively correlated. Global H4 acetylation was positively correlated with disease activity and expression of HDAC2 protein was negatively correlated with skin thickness 
520 |a CONCLUSIONS: Histone modifications were altered in B cells in SSc correlating with skin thickness and disease activity 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Acetylation 
650 4 |a B cells 
650 4 |a Histone modification 
650 4 |a Methylation 
650 4 |a Systemic sclerosis 
650 7 |a Histones  |2 NLM 
650 7 |a RNA, Messenger  |2 NLM 
650 7 |a Jumonji Domain-Containing Histone Demethylases  |2 NLM 
650 7 |a EC 1.14.11.-  |2 NLM 
650 7 |a Histone-Lysine N-Methyltransferase  |2 NLM 
650 7 |a EC 2.1.1.43  |2 NLM 
650 7 |a SUV39H2 protein, human  |2 NLM 
650 7 |a EC 2.1.1.43  |2 NLM 
650 7 |a HDAC2 protein, human  |2 NLM 
650 7 |a EC 3.5.1.98  |2 NLM 
650 7 |a HDAC7 protein, human  |2 NLM 
650 7 |a EC 3.5.1.98  |2 NLM 
650 7 |a Histone Deacetylase 2  |2 NLM 
650 7 |a EC 3.5.1.98  |2 NLM 
650 7 |a Histone Deacetylases  |2 NLM 
650 7 |a EC 3.5.1.98  |2 NLM 
700 1 |a Yang, Yan  |e verfasserin  |4 aut 
700 1 |a Luo, YangYang  |e verfasserin  |4 aut 
700 1 |a Yin, YongXin  |e verfasserin  |4 aut 
700 1 |a Wang, Qing  |e verfasserin  |4 aut 
700 1 |a Li, YaPing  |e verfasserin  |4 aut 
700 1 |a Kanekura, Takuro  |e verfasserin  |4 aut 
700 1 |a Wang, JiuCun  |e verfasserin  |4 aut 
700 1 |a Liang, GongPing  |e verfasserin  |4 aut 
700 1 |a Zhao, Ming  |e verfasserin  |4 aut 
700 1 |a Lu, QianJin  |e verfasserin  |4 aut 
700 1 |a Xiao, Rong  |e verfasserin  |4 aut 
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