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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la401858s
|2 doi
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|a pubmed24n0764.xml
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|a (NLM)23865752
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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1 |
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|a Zvarec, Ondrej
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Catechol-functionalized chitosan/iron oxide nanoparticle composite inspired by mussel thread coating and squid beak interfacial chemistry
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.03.2014
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Biological materials offer a wide range of multifunctional and structural properties that are currently not achieved in synthetic materials. Herein we report on the synthesis and preparation of bioinspired organic/inorganic composites that mimic the key physicochemical features associated with the mechanical strengthening of both squid beaks and mussel thread coatings using chitosan as an initial template. While chitosan is a well-known biocompatible material, it suffers from key drawbacks that have limited its usage in a wider range of structural biomedical applications. First, its load-bearing capability in hydrated conditions remains poor, and second it completely dissolves at pH < 6, preventing its use in mild acidic microenvironments. In order to overcome these intrinsic limitations, a chitosan-based organic/inorganic biocomposite is prepared that mimics the interfacial chemistry of squid beaks and mussel thread coating. Chitosan was functionalized with catechol moieties in a highly controlled fashion and combined with superparamagnetic iron oxide (γ-Fe2O3) nanoparticles to give composites that represent a significant improvement in functionality of chitosan-based biomaterials. The inorganic/organic (γ-Fe2O3/catechol) interfaces are stabilized and strengthened by coordination bonding, resulting in hybrid composites with improved stability at high temperatures, physiological pH conditions, and acid/base conditions. The inclusion of superparamagnetic particles also makes the composites stimuli-responsive
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Catechols
|2 NLM
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|a Ferric Compounds
|2 NLM
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|a ferric oxide
|2 NLM
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|a 1K09F3G675
|2 NLM
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|a Chitosan
|2 NLM
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|a 9012-76-4
|2 NLM
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| 650 |
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|a catechol
|2 NLM
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| 650 |
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7 |
|a LF3AJ089DQ
|2 NLM
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| 700 |
1 |
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|a Purushotham, Sreekanth
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Masic, Admir
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ramanujan, Raju V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miserez, Ali
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 34 vom: 27. Aug., Seite 10899-906
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2013
|g number:34
|g day:27
|g month:08
|g pages:10899-906
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|u http://dx.doi.org/10.1021/la401858s
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