Oxidative stress biomarkers in freshwater fish Carassius auratus exposed to decabromodiphenyl ether and ethane, or their mixture

Decabromodiphenyl ether (BDE-209) and its commercial alternative decabromodiphenyl ethane (DBDPE) are two structurally similar brominated flame retardants, with evidence of their ubiquitous existence in aquatic ecosystems. The present study was conducted to investigate the hepatic oxidative stress i...

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Veröffentlicht in:Ecotoxicology (London, England). - 1992. - 22(2013), 7 vom: 06. Sept., Seite 1101-10
1. Verfasser: Feng, Mingbao (VerfasserIn)
Weitere Verfasser: Li, Ying, Qu, Ruijuan, Wang, Liansheng, Wang, Zunyao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Ecotoxicology (London, England)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Biomarkers Bromobenzenes Flame Retardants Halogenated Diphenyl Ethers Water Pollutants, Chemical decabromodiphenyl ethane Malondialdehyde 4Y8F71G49Q mehr... Glutathione GAN16C9B8O decabromobiphenyl ether N80BQ29A0H
Beschreibung
Zusammenfassung:Decabromodiphenyl ether (BDE-209) and its commercial alternative decabromodiphenyl ethane (DBDPE) are two structurally similar brominated flame retardants, with evidence of their ubiquitous existence in aquatic ecosystems. The present study was conducted to investigate the hepatic oxidative stress inducing potential of BDE-209, DBDPE, and their mixture in Carassius auratus after exposure to different doses (10, 50 and 100 mg/kg) for 7, 14 and 30 days. Results showed that oxidative stress was evoked evidently for the experimental groups with longer exposure duration, as indicated by significant inhibition in the antioxidant enzymes activities and decrease in the reduced glutathione level, as well as simultaneous elevation of lipid peroxidation level measured by malondialdehyde content. In addition, it was found that BDE-209 possessed a higher oxidative stress inducing ability than DBDPE. Considering the more pronounced antioxidant responses in combined exposure, the interaction of BDE-209 and DBDPE was presumed to be additive action
Beschreibung:Date Completed 03.03.2014
Date Revised 21.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1573-3017
DOI:10.1007/s10646-013-1097-2