Crystalline calcium alendronate obtained by octacalcium phosphate digestion a new chance for local treatment of bone loss diseases?

Crystalline calcium alendronate obtained by octacalcium phosphate digestion : a new chance for local treatment of bone loss diseases?

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 33 vom: 06. Sept., Seite 4605-11
1. Verfasser: Boanini, Elisa (VerfasserIn)
Weitere Verfasser: Torricelli, Paola, Gazzano, Massimo, Fini, Milena, Bigi, Adriana
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't bisphosphonate in vitro co-cultures octacalcium phosphate Calcium Phosphates Calcium SY7Q814VUP Alendronate X1J18R4W8P
Beschreibung
Zusammenfassung:Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP
Beschreibung:Date Completed 01.05.2014
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201301129