Up-regulation of heme oxygenase-1 contributes to the amelioration of aluminum-induced oxidative stress in Medicago sativa

Up-regulation of heme oxygenase-1 contributes to the amelioration of aluminum-induced oxidative stress in Medicago sativa

Copyright © 2013 Elsevier GmbH. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Journal of plant physiology. - 1979. - 170(2013), 15 vom: 15. Okt., Seite 1328-36
1. Verfasser: Cui, Weiti (VerfasserIn)
Weitere Verfasser: Zhang, Jing, Xuan, Wei, Xie, Yanjie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Journal of plant physiology
Schlagworte:Journal Article Research Support, Non-U.S. Gov't APX ASC Al Aluminum toxicity BHA BHT BR BV mehr... CAT CO Carbon monoxide G6PDH GPX GR GST HO HO-1 Heme oxygenase-1 Medicago sativa NO Oxidative stress POD ROS SOD TBARS ZnPP aluminum ascorbate peroxidase ascorbic acid bilirubin biliverdin butylated hydroxyanisole butylated hydroxytoluene carbon monoxide catalase glucose-6-phosphate-dehydrogenase glutathione S-transferase glutathione peroxidase glutathione reductase guaiacol peroxidase heme oxygenase heme oxygenase-1 nitric oxide reactive oxygen species superoxide dismutase thiobarbituric acid reactive substances zinc protoporphyrin IX Aluminum CPD4NFA903 Heme Oxygenase-1 EC 1.14.14.18
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520 |a Copyright © 2013 Elsevier GmbH. All rights reserved. 
520 |a In this report, pharmacological, histochemical and molecular approaches were used to investigate the effect of heme oxygenase-1 (HO-1) up-regulation on the alleviation of aluminum (Al)-induced oxidative stress in Medicago sativa. Exposure of alfalfa to AlCl3 (0-100 μM) resulted in a dose-dependent inhibition of root elongation as well as the enhancement of thiobarbituric acid reactive substances (TBARS) content. 1 and 10 μM (in particular) Al(3+) increased alfalfa HO-1 transcript or its protein level, and HO activity in comparison with the decreased changes in 100 μM Al-treated samples. After recuperation, however, TBARS levels in 1 and 10 μM Al-treated alfalfa roots returned to control values, which were accompanied with the higher levels of HO activity. Subsequently, exogenous CO, a byproduct of HO-1, could substitute for the cytoprotective effects of the up-regulation of HO-1 in alfalfa plants upon Al stress, which was confirmed by the alleviation of TBARS and Al accumulation, as well as the histochemical analysis of lipid peroxidation and loss of plasma membrane integrity. Theses results indicated that endogenous CO generated via heme degradation by HO-1 could contribute in a critical manner to its protective effects. Additionally, the pretreatments of butylated hydroxytoluene (BHT) and hemin, an inducer of HO-1, exhibited the similar cytoprotective roles in the alleviation of oxidative stress, both of which were impaired by the potent inhibitor of HO-1, zinc protoporphyrin IX (ZnPP). However, the Al-induced inhibition of root elongation was not influenced by CO, BHT and hemin, respectively. Together, the present results showed up-regulation of HO-1 expression could act as a mechanism of cell protection against oxidative stress induced by Al treatment 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a APX 
650 4 |a ASC 
650 4 |a Al 
650 4 |a Aluminum toxicity 
650 4 |a BHA 
650 4 |a BHT 
650 4 |a BR 
650 4 |a BV 
650 4 |a CAT 
650 4 |a CO 
650 4 |a Carbon monoxide 
650 4 |a G6PDH 
650 4 |a GPX 
650 4 |a GR 
650 4 |a GST 
650 4 |a HO 
650 4 |a HO-1 
650 4 |a Heme oxygenase-1 
650 4 |a Medicago sativa 
650 4 |a NO 
650 4 |a Oxidative stress 
650 4 |a POD 
650 4 |a ROS 
650 4 |a SOD 
650 4 |a TBARS 
650 4 |a ZnPP 
650 4 |a aluminum 
650 4 |a ascorbate peroxidase 
650 4 |a ascorbic acid 
650 4 |a bilirubin 
650 4 |a biliverdin 
650 4 |a butylated hydroxyanisole 
650 4 |a butylated hydroxytoluene 
650 4 |a carbon monoxide 
650 4 |a catalase 
650 4 |a glucose-6-phosphate-dehydrogenase 
650 4 |a glutathione S-transferase 
650 4 |a glutathione peroxidase 
650 4 |a glutathione reductase 
650 4 |a guaiacol peroxidase 
650 4 |a heme oxygenase 
650 4 |a heme oxygenase-1 
650 4 |a nitric oxide 
650 4 |a reactive oxygen species 
650 4 |a superoxide dismutase 
650 4 |a thiobarbituric acid reactive substances 
650 4 |a zinc protoporphyrin IX 
650 7 |a Aluminum  |2 NLM 
650 7 |a CPD4NFA903  |2 NLM 
650 7 |a Heme Oxygenase-1  |2 NLM 
650 7 |a EC 1.14.14.18  |2 NLM 
700 1 |a Zhang, Jing  |e verfasserin  |4 aut 
700 1 |a Xuan, Wei  |e verfasserin  |4 aut 
700 1 |a Xie, Yanjie  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Journal of plant physiology  |d 1979  |g 170(2013), 15 vom: 15. Okt., Seite 1328-36  |w (DE-627)NLM098174622  |x 1618-1328  |7 nnns 
773 1 8 |g volume:170  |g year:2013  |g number:15  |g day:15  |g month:10  |g pages:1328-36 
856 4 0 |u http://dx.doi.org/10.1016/j.jplph.2013.05.014  |3 Volltext 
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