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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la4008894
|2 doi
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|a pubmed24n0761.xml
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|a (DE-627)NLM228481538
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|a (NLM)23782319
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kaplan, Justin M
|e verfasserin
|4 aut
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| 245 |
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|a Conformationally constrained functional peptide monolayers for the controlled display of bioactive carbohydrate ligands
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.01.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this study, we employed thiolated peptides of the conformationally constrained, strongly helicogenic α-aminoisobutyric acid (Aib) residue to prepare self-assembled monolayers (SAMs) on gold surfaces. Electrochemistry and infrared reflection absorption spectroscopy support the formation of very well packed Aib-peptide SAMs. The immobilized peptides retain their helical structure, and the resulting SAMs are stabilized by a network of intermolecular H bonds involving the NH groups adjacent to the Au surface. Binary SAMs containing a synthetically defined glycosylated mannose-functionalized Aib-peptide as the second component display similar features, thereby providing reproducible substrates suitable for the controlled display of bioactive carbohydrate ligands. The efficiency of such Aib-based SAMs as a biomolecular recognition platform was evidenced by examining the mannose-concanavalin A interaction via surface plasmon resonance biosensing
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Aminoisobutyric Acids
|2 NLM
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|a Immobilized Proteins
|2 NLM
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|a Peptides
|2 NLM
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|a Sulfhydryl Compounds
|2 NLM
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|a Concanavalin A
|2 NLM
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|a 11028-71-0
|2 NLM
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| 650 |
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|a 2-aminoisobutyric acid
|2 NLM
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| 650 |
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|a 1E7ZW41IQU
|2 NLM
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| 650 |
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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| 650 |
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|a Mannose
|2 NLM
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| 650 |
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|a PHA4727WTP
|2 NLM
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| 700 |
1 |
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|a Shang, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gobbo, Pierangelo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Antonello, Sabrina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Armelao, Lidia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chatare, Vijay
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ratner, Daniel M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andrade, Rodrigo B
|e verfasserin
|4 aut
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| 700 |
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|a Maran, Flavio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 26 vom: 02. Juli, Seite 8187-92
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:29
|g year:2013
|g number:26
|g day:02
|g month:07
|g pages:8187-92
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|u http://dx.doi.org/10.1021/la4008894
|3 Volltext
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