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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.05.013
|2 doi
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|a pubmed24n0761.xml
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|a (PII)S1521-6616(13)00133-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Lim, Dong-Gyun
|e verfasserin
|4 aut
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|a Diagnostic value of tolerance-related gene expression measured in the recipient alloantigen-reactive T cell fraction
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.09.2013
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a The efficient development of tolerance-inducing therapies and safe reduction of immunosuppression should be supported by early diagnosis and prediction of tolerance in transplantation. Using mouse models of donor-specific tolerance to allogeneic skin and islet grafts we tested whether measurement of tolerance-related gene expression in their alloantigen-reactive peripheral T cell fraction efficiently reflected the tolerance status of recipients. We found that Foxp3, Nrn1, and Klrg1 were preferentially expressed in conditions of tolerance compared with rejection or unmanipulated controls if their expression is measured in CD69(+) T cells prepared from coculture of recipient peripheral T cells and donor antigen-presenting cells. The same pattern of gene expression was observed in recipients grafted with either skin or islets, recipients of different genetic origins, and even those taking immunosuppressive drugs. These findings suggest that the expression of tolerance-related genes in the alloantigen-reactive T cell fraction could be used to detect tolerance in the clinic
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a APC
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|a Alloreactive T cells
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|a CsA
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|a DST
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|a Gene expression
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|a Immune monitoring
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|a Tolerance
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|a antigen-presenting cell
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|a cyclosporine A
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|a donor-specific transfusion
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|a mPD
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|a methylprednisolone
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|a qRT-PCR
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|a quantitative reverse-transcription polymerase chain reaction
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|a Immunosuppressive Agents
|2 NLM
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|a Isoantigens
|2 NLM
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|a Cyclosporine
|2 NLM
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|a 83HN0GTJ6D
|2 NLM
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|a Sirolimus
|2 NLM
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|a W36ZG6FT64
|2 NLM
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| 700 |
1 |
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|a Park, Youn-Hee
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Sung-Eun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jeong, Seong-Hee
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Song-Cheol
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 148(2013), 2 vom: 15. Aug., Seite 219-26
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:148
|g year:2013
|g number:2
|g day:15
|g month:08
|g pages:219-26
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|u http://dx.doi.org/10.1016/j.clim.2013.05.013
|3 Volltext
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