Easy design of colorimetric logic gates based on nonnatural base pairing and controlled assembly of gold nanoparticles

Utilizing the principles of metal-ion-mediated base pairs (C-Ag-C and T-Hg-T), the pH-sensitive conformational transition of C-rich DNA strand, and the ligand-exchange process triggered by DL-dithiothreitol (DTT), a system of colorimetric logic gates (YES, AND, INHIBIT, and XOR) can be rationally co...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 29(2013), 28 vom: 16. Juli, Seite 8929-35
1. Verfasser: Zhang, Li (VerfasserIn)
Weitere Verfasser: Wang, Zhong-Xia, Liang, Ru-Ping, Qiu, Jian-Ding
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Gold 7440-57-5 DNA 9007-49-2 Dithiothreitol T8ID5YZU6Y
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520 |a Utilizing the principles of metal-ion-mediated base pairs (C-Ag-C and T-Hg-T), the pH-sensitive conformational transition of C-rich DNA strand, and the ligand-exchange process triggered by DL-dithiothreitol (DTT), a system of colorimetric logic gates (YES, AND, INHIBIT, and XOR) can be rationally constructed based on the aggregation of the DNA-modified Au NPs. The proposed logic operation system is simple, which consists of only T-/C-rich DNA-modified Au NPs, and it is unnecessary to exquisitely design and alter the DNA sequence for different multiple molecular logic operations. The nonnatural base pairing combined with unique optical properties of Au NPs promises great potential in multiplexed ion sensing, molecular-scale computers, and other computational logic devices 
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700 1 |a Liang, Ru-Ping  |e verfasserin  |4 aut 
700 1 |a Qiu, Jian-Ding  |e verfasserin  |4 aut 
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