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01000naa a22002652 4500 |
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NLM228382548 |
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DE-627 |
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20231224075802.0 |
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cr uuu---uuuuu |
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231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2013.05.015
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0761.xml
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|a (DE-627)NLM228382548
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|a (NLM)23770629
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| 035 |
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|a (PII)S1521-6616(13)00135-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Castañeda-Delgado, J E
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Production of antimicrobial peptides is preserved in aging
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| 264 |
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1 |
|c 2013
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 17.09.2013
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| 500 |
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|a Date Revised 07.12.2022
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a There is an increased susceptibility to infections during elderly, mainly because of the decreased efficacy of adaptive immunity to contain microorganisms. Albeit most of the elderly adults develop this deficiency in adaptive immunity only a minor percentage of them developed recurrent infectious diseases, thus innate immunity represents an important barrier to avoid infections in this group of aged people. Since antimicrobial peptides are important molecules of innate immunity in the study we sought to determine whether healthy aging correlates with a proper antimicrobial production. Our results by ELISA and flow cytometry showed that healthy elder individuals produce significant amounts of both cathelicidin and β-defensin-2 (hBD-2) comparable with those found in healthy young individuals. Our results suggest that during healthy aging the maintenance of the antimicrobial peptide innate immune response may be responsible for the protection against infectious diseases
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Aging;
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| 650 |
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4 |
|a Defensin;
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| 650 |
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4 |
|a Immunosenescence;
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| 650 |
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4 |
|a Innate immunity
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| 650 |
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4 |
|a LL-37;
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| 650 |
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7 |
|a Antimicrobial Cationic Peptides
|2 NLM
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| 650 |
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7 |
|a DEFB4A protein, human
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a beta-Defensins
|2 NLM
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| 650 |
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7 |
|a Cathelicidins
|2 NLM
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| 700 |
1 |
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|a Miranda-Castro, N Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a González-Amaro, R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a González-Curiel, I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Montoya-Rosales, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rivas-Calderon, B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rivas-Santiago, B
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 148(2013), 2 vom: 15. Aug., Seite 198-205
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:148
|g year:2013
|g number:2
|g day:15
|g month:08
|g pages:198-205
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2013.05.015
|3 Volltext
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|a AR
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| 952 |
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|d 148
|j 2013
|e 2
|b 15
|c 08
|h 198-205
|