3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 32 vom: 27. Aug., Seite 4459-65
1. Verfasser: Kolewe, Martin E (VerfasserIn)
Weitere Verfasser: Park, Hyoungshin, Gray, Caprice, Ye, Xiaofeng, Langer, Robert, Freed, Lisa E
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural alignment heart microfabrication muscle polyglycerol sebacate (PGS) Decanoates Elastomers Polymers mehr... elastomeric polymer poly(glycerol-sebacate) Glycerol PDC6A3C0OX
Beschreibung
Zusammenfassung:Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions
Beschreibung:Date Completed 10.03.2014
Date Revised 18.03.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201301016