Computational gibberellin-binding channel discovery unraveling the unexpected perception mechanism of hormone signal by gibberellin receptor
Copyright © 2013 Wiley Periodicals, Inc.
| Publié dans: | Journal of computational chemistry. - 1984. - 34(2013), 24 vom: 15. Sept., Seite 2055-64 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2013
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| Accès à la collection: | Journal of computational chemistry |
| Sujets: | Journal Article binding free energy gibberellin hormone perception mechanism plant hormone protein-ligand interaction Arabidopsis Proteins GID1a protein, Arabidopsis Gibberellins Plant Growth Regulators |
| Résumé: | Copyright © 2013 Wiley Periodicals, Inc. Gibberellins (GAs) are phytohormones essential for many developmental processes in plants. In this work, fundamental mechanism of hormone perception by receptor GID1 has been studied by performing computational simulations, revealing a new GA-binding channel of GID1 and a novel hormone perception mechanism involving only one conformational state of GID1. The novel hormone perception mechanism demonstrated here is remarkably different from the previously proposed/speculated mechanism [Murase et al., Nature 2008, 456, 459] involving two conformational states ("OPEN" and "CLOSED") of GID1. According to the new perception mechanism, GA acts as a "conformational stabilizer," rather than the previously speculated "allosteric inducer," to induce the recognition of protein DELLA by GID1. The novel mechanistic insights obtained in this study provide a new starting point for further studies on the detailed molecular mechanisms of GID1 interacting with DELLA and various hormones and for mechanism-based rational design of novel, potent growth regulators that target crops and ornamental plants |
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| Description: | Date Completed 21.02.2014 Date Revised 06.08.2013 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1096-987X |
| DOI: | 10.1002/jcc.23355 |