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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la401423d
|2 doi
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|a pubmed24n0760.xml
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|a eng
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| 100 |
1 |
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|a Chen, Dongdong
|e verfasserin
|4 aut
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|a Robust and flexible free-standing films for unidirectional drug delivery
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 22.01.2014
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|a Date Revised 03.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Robust and flexible free-standing polymer films for unidirectional drug delivery are fabricated by sandwiching drug-containing polyelectrolyte multilayer films between poly(lactic-co-glycolic acid) (PLGA) barrier and capping layers. The drug-containing films are fabricated by layer-by-layer (LbL) assembly of chemically cross-linked poly(allylamine hydrochloride)-dextran (PAH-D) microgel and hyaluronic acid (HA), which can load negatively charged cancer-inhibiting drug, methotrexate (MTX). Because the PLGA barrier layer effectively blocks MTX release, MTX can be predominantly released from the PLGA capping layer of the free-standing film. This increases the efficacy of released MTX to cancer cells while minimizing its side effects on the normal tissues. We believe that the unidirectional drug delivery free-standing films can open a new avenue to design of highly efficient drug delivery systems for biomedical application
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antimetabolites, Antineoplastic
|2 NLM
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|a Dextrans
|2 NLM
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|a Gels
|2 NLM
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|a Polyamines
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|a Polylactic Acid-Polyglycolic Acid Copolymer
|2 NLM
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|a 1SIA8062RS
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|a Polyglycolic Acid
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|a polyallylamine
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|a Lactic Acid
|2 NLM
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|a Hyaluronic Acid
|2 NLM
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| 650 |
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|a 9004-61-9
|2 NLM
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| 650 |
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|a Methotrexate
|2 NLM
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| 650 |
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|a YL5FZ2Y5U1
|2 NLM
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| 700 |
1 |
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|a Chen, Jie
|e verfasserin
|4 aut
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1 |
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|a Wu, Mingda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Huayu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xuesi
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Junqi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 26 vom: 02. Juli, Seite 8328-34
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:29
|g year:2013
|g number:26
|g day:02
|g month:07
|g pages:8328-34
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|u http://dx.doi.org/10.1021/la401423d
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