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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la400011n
|2 doi
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|a pubmed24n0760.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Wang, Chih-Wei
|e verfasserin
|4 aut
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|a Flow-directed loading of block copolymer micelles with hydrophobic probes in a gas-liquid microreactor
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|c 2013
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.01.2014
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|a Date Revised 02.07.2013
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a We investigate the loading efficiencies of two chemically distinct hydrophobic fluorescent probes, pyrene and naphthalene, for self-assembly and loading of polystyrene-block-poly(acrylic acid) (PS-b-PAA) micelles in gas-liquid segmented microfluidic reactors under different chemical and flow conditions. On-chip loading efficiencies are compared to values obtained via off-chip dropwise water addition to a solution of copolymer and probe. On-chip, probe loading efficiencies depend strongly on the chemical probe, initial solvent, water content, and flow rate. For pyrene and naphthalene probes, maximum on-chip loading efficiencies of 73 ± 6% and 11 ± 3%, respectively, are obtained, in both cases using the more polar solvent (DMF), an intermediate water content (2 wt % above critical), and a low flow rate (∼5 μL/min); these values are compared to 81 ± 6% and 48 ± 2%, respectively, for off-chip loading. On-chip loading shows a significant improvement over the off-chip process where shear-induced formation of smaller micelles enables increased encapsulation of probe. As well, we show that on-chip loading allows off-chip release kinetics to be controlled via flow rate: compared to vehicles produced at ∼5 μL/min, pyrene release kinetics from vehicles produced at ∼50 μL/min showed a longer initial period of burst release, followed by slow release over a longer total period. These results demonstrate the necessity to match probes, solvents, and running conditions to achieve effective loading, which is essential information for further developing these on-chip platforms for manufacturing drug delivery formulations
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|a Journal Article
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|a Bains, Aman
|e verfasserin
|4 aut
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|a Sinton, David
|e verfasserin
|4 aut
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|a Moffitt, Matthew G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 26 vom: 02. Juli, Seite 8385-94
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|x 1520-5827
|7 nnns
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|g volume:29
|g year:2013
|g number:26
|g day:02
|g month:07
|g pages:8385-94
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|u http://dx.doi.org/10.1021/la400011n
|3 Volltext
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