A suspected case of extra-gonadal germ cell tumor complicated with choriocarcinoma syndrome

Our patient was a 31-year-old man who presented with right flank pain. Computed tomography revealed multiple tumors in the liver and lungs, with marked elevation of serum human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) levels. In addition, no testicular abnormalities were detected by...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 59(2013), 5 vom: 26. Mai, Seite 309-14
1. Verfasser: Nakamura, Masafumi (VerfasserIn)
Weitere Verfasser: Hanai, Takahiro, Sanjyo, Hiroyuki, Yasuda, Kengo, Takamoto, Daiji, Gohbara, Ayako, Teranishi, Jun-ichi, Yumura, Yasushi, Miyoshi, Yasuhide, Kondo, Keiichi, Noguchi, Kazumi
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Case Reports English Abstract Journal Article Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic Agents, Phytogenic Chorionic Gonadotropin alpha-Fetoproteins Bleomycin 11056-06-7 mehr... Etoposide 6PLQ3CP4P3 Cisplatin Q20Q21Q62J
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245 1 2 |a A suspected case of extra-gonadal germ cell tumor complicated with choriocarcinoma syndrome 
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520 |a Our patient was a 31-year-old man who presented with right flank pain. Computed tomography revealed multiple tumors in the liver and lungs, with marked elevation of serum human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) levels. In addition, no testicular abnormalities were detected by palpation or ultrasonography. On the bases of these results, the patient was diagnosed with extragonadal germ cell tumor and was therefore started on chemotherapy with bleomycin, etoposide, and cisplatin (BEP). However, the result of a subsequent blood test showed marked pancytopenia at the initial stage of treatment. We speculated that the cause of anemia was not only bone marrow suppression but also intratumoral hemorrhage, collectively termed choriocarcinoma syndrome. After conservative treatment involving blood transfusion and administration of granulocyte colony-stimulating factor, he recovered. After several chemotherapy sessions, the levels of all tumor markers returned to normal. Finally, the patient underwent hepatectomy for residual tumors ; but, the resected specimen showed no viable cancer cells. Currently, the patient is free from disease since the last chemotherapy session, administered 5 months ago 
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700 1 |a Hanai, Takahiro  |e verfasserin  |4 aut 
700 1 |a Sanjyo, Hiroyuki  |e verfasserin  |4 aut 
700 1 |a Yasuda, Kengo  |e verfasserin  |4 aut 
700 1 |a Takamoto, Daiji  |e verfasserin  |4 aut 
700 1 |a Gohbara, Ayako  |e verfasserin  |4 aut 
700 1 |a Teranishi, Jun-ichi  |e verfasserin  |4 aut 
700 1 |a Yumura, Yasushi  |e verfasserin  |4 aut 
700 1 |a Miyoshi, Yasuhide  |e verfasserin  |4 aut 
700 1 |a Kondo, Keiichi  |e verfasserin  |4 aut 
700 1 |a Noguchi, Kazumi  |e verfasserin  |4 aut 
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