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231224s2013 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.201300823
|2 doi
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|a pubmed24n1435.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Chien, Miao-Ping
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Enzyme-directed assembly of a nanoparticle probe in tumor tissue
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 27.03.2014
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|a Date Revised 10.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a enzyme-responsive
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|a in vivo probe
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| 650 |
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|a micelle
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| 650 |
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4 |
|a nanoparticles
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| 650 |
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4 |
|a peptide
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| 650 |
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|a Molecular Probes
|2 NLM
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| 650 |
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|a Peptides
|2 NLM
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| 650 |
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|a Polymers
|2 NLM
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| 650 |
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|a Matrix Metalloproteinase 2
|2 NLM
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|a EC 3.4.24.24
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| 650 |
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| 700 |
1 |
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|a Thompson, Matthew P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Barback, Christopher V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ku, Ti-Hsuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hall, David J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gianneschi, Nathan C
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 25(2013), 26 vom: 12. Juli, Seite 3599-604
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:25
|g year:2013
|g number:26
|g day:12
|g month:07
|g pages:3599-604
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|u http://dx.doi.org/10.1002/adma.201300823
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