Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄SiO₂ for simultaneous tumor cell targeting and stimulus-induced drug release

Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄SiO₂ for simultaneous tumor cell targeting and stimulus-induced drug release

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 25 vom: 05. Juli, Seite 3485-9
1. Verfasser: Wang, Feng (VerfasserIn)
Weitere Verfasser: Pauletti, Giovanni M, Wang, Juntao, Zhang, Jiaming, Ewing, Rodney C, Wang, Yilong, Shi, Donglu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Janus nanocomposites drug delivery dual-functionality targeting Drug Carriers Polystyrenes Silicon Dioxide 7631-86-9 mehr... Doxorubicin 80168379AG Ferrosoferric Oxide XM0M87F357
Beschreibung
Zusammenfassung:Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3 O4 SiO2 and polystyrene surfaces of a unique polystyrene/Fe3 O4 @SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments
Beschreibung:Date Completed 06.01.2014
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201301376