Plasma proteins adsorption mechanism on polyethylene-grafted poly(ethylene glycol) surface by quartz crystal microbalance with dissipation

Protein adsorption has a vital role in biomaterial surface science because it is directly related to the hemocompatibility of blood-contacting materials. In this study, monomethoxy poly(ethylene glycol) (mPEG) with two different molecular weights was grafted on polyethylene as a model to elucidate t...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 29(2013), 22 vom: 04. Juni, Seite 6624-33
1. Verfasser: Jin, Jing (VerfasserIn)
Weitere Verfasser: Jiang, Wei, Yin, Jinghua, Ji, Xiangling, Stagnaro, Paola
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Blood Proteins Serum Albumin, Bovine 27432CM55Q Polyethylene Glycols 3WJQ0SDW1A Fibrinogen 9001-32-5 Polyethylene mehr... 9002-88-4 monomethoxypolyethylene glycol 9004-74-4
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500 |a Citation Status MEDLINE 
520 |a Protein adsorption has a vital role in biomaterial surface science because it is directly related to the hemocompatibility of blood-contacting materials. In this study, monomethoxy poly(ethylene glycol) (mPEG) with two different molecular weights was grafted on polyethylene as a model to elucidate the adsorption mechanisms of plasma protein through quartz crystal microbalance with dissipation (QCM-D). Combined with data from platelet adhesion, whole blood clotting time, and hemolysis rate, the blood compatibility of PE-g-mPEG film was found to have significantly improved. Two adsorption schemes were developed for real-time monitoring of protein adsorption. Results showed that the preadsorbed bovine serum albumin (BSA) on the surfaces of PE-g-mPEG films could effectively inhibit subsequent adsorption of fibrinogen (Fib). Nonspecific protein adsorption of BSA was determined by surface coverage, not by the chain length of PEG. Dense PEG brush could release more trapped water molecules to resist BSA adsorption. Moreover, the preadsorbed Fib could be gradually displaced by high-concentration BSA. However, the adsorption and displacement of Fib was determined by surface hydrophilicity 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a Serum Albumin, Bovine  |2 NLM 
650 7 |a 27432CM55Q  |2 NLM 
650 7 |a Polyethylene Glycols  |2 NLM 
650 7 |a 3WJQ0SDW1A  |2 NLM 
650 7 |a Fibrinogen  |2 NLM 
650 7 |a 9001-32-5  |2 NLM 
650 7 |a Polyethylene  |2 NLM 
650 7 |a 9002-88-4  |2 NLM 
650 7 |a monomethoxypolyethylene glycol  |2 NLM 
650 7 |a 9004-74-4  |2 NLM 
700 1 |a Jiang, Wei  |e verfasserin  |4 aut 
700 1 |a Yin, Jinghua  |e verfasserin  |4 aut 
700 1 |a Ji, Xiangling  |e verfasserin  |4 aut 
700 1 |a Stagnaro, Paola  |e verfasserin  |4 aut 
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