Reprint of : B cell elimination in systemic lupus erythematosus. Clin. Immunol. 146(2) 90-103
Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 148(2013), 3 vom: 01. Sept., Seite 344-58 |
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| Auteur principal: | |
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| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2013
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article ALMS APRIL APS Aspreva Lupus Management Study B cell depletion B cell depletion therapy B lymphocyte stimulator protein BCDT BILAG plus... |
| Résumé: | Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved. Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution, potentially life-threatening with considerable morbidity. The elimination of pathogenic B cells has emerged as a rational therapeutic option. Many open label studies have reported encouraging results in which clinical and serological remission have invariably been described, often enabling the reduction of steroid and immunosuppressive treatment. However, the results from randomized controlled studies have been disappointing and several questions remain to be answered. In this review we will focus on results of B cell direct depletion in the treatment of patients with systemic lupus erythematosus |
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| Description: | Date Completed 23.10.2013 Date Revised 07.08.2013 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2013.04.001 |