Luminescent carbon dot-gated nanovehicles for pH-triggered intracellular controlled release and imaging
In this paper, the use of biocompatible carbon dots (C-Dots) as caps on the surface of mesoporous silica nanoparticles (MSPs) for the design of intelligent on-demand molecular delivery and cell imaging system is described. These C-Dots-attached MSPs exhibited low cytotoxicity toward the cells and st...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 29(2013), 21 vom: 28. Mai, Seite 6396-403 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Antineoplastic Agents Carbon 7440-44-0 Silicon Dioxide 7631-86-9 Doxorubicin 80168379AG |
| Zusammenfassung: | In this paper, the use of biocompatible carbon dots (C-Dots) as caps on the surface of mesoporous silica nanoparticles (MSPs) for the design of intelligent on-demand molecular delivery and cell imaging system is described. These C-Dots-attached MSPs exhibited low cytotoxicity toward the cells and strong luminescence both in vitro and in vivo. A further loading of anticancer drug (DOX) endowed the fluorescent material with therapeutic functions. It was found that changing the pH to mildly acidic condition at physiological temperature caused the dissociation of the C-DotsMSPs complex and release of a large number of DOX from the nanospheres. Moreover, the DOX-loaded nanocomposites exhibited a remarkably enhanced efficiency in killing cancer cells. The endocytosis and the efficient drug release properties of the system were confirmed by luminescence microscopy. Overall, we believe that the well-designed C-Dots@MSPs nanocomposites are promising for a simultaneous bioimaging and drug delivery system, which show more potential for clinical application |
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| Beschreibung: | Date Completed 14.01.2014 Date Revised 28.05.2013 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la400479n |