Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent

Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent

A bacteria-targeted MR contrast agent, Zn-1, consisting of two Zn-dipicolylamine (Zn-dpa) groups conjugated to a GdIII chelate has been synthesized and characterized. In vitro studies with S. aureus and E. coli show that Zn-1 exhibits a significant improvement in bacteria labeling efficiency vs. con...

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Bibliographische Detailangaben
Veröffentlicht in:European journal of inorganic chemistry. - 1998. - 2012(2012), 12 vom: 01. Apr., Seite 2099-2107
1. Verfasser: Matosziuk, Lauren M (VerfasserIn)
Weitere Verfasser: Harney, Allison S, Macrenaris, Keith W, Meade, Thomas J
Format: Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:European journal of inorganic chemistry
Schlagworte:Journal Article Bacteria labeling Imaging agents Magnetic resonance imaging Medicinal chemistry Zinc