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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.02.018
|2 doi
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|a pubmed24n0755.xml
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|a eng
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|a Tardif, Virginie
|e verfasserin
|4 aut
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|a Critical role of transmethylation in TLR signaling and systemic lupus erythematosus
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 20.06.2013
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a Post-translational protein modifications can play a significant role in immune cell signaling. Recently, we showed that inhibition of transmethylation curtails experimental autoimmune encephalomyelitis, notably by reducing T cell receptor (TCR)-induced activation of CD4(+) T cells. Here, we demonstrate that transmethylation inhibition by a reversible S-adenosyl-l-homocysteine hydrolase inhibitor (DZ2002) led to immunosuppression by reducing TLR-, B cell receptor (BCR)- and TCR-induced activation of immune cells, most likely by blocking NF-κB activity. Moreover, prophylactic treatment with DZ2002 prevented lupus-like disease from developing in both BXSB and MRL-Fas(lpr) mouse models. DZ2002 treatment initiated during active disease significantly improved outcomes in both in vivo models, suggesting methylation inhibition as a novel approach for the treatment of autoimmune/inflammatory diseases
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Autoantibodies
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|a Butyrates
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|a Cytokines
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|a Immunoglobulin G
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|a Immunosuppressive Agents
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|a NF-kappa B
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|a Toll-Like Receptors
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|a methyl 4-(adenin-9-yl)-2-hydroxybutanoate
|2 NLM
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|a JAC85A2161
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|a Manenkova, Yulia
|e verfasserin
|4 aut
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|a Berger, Michael
|e verfasserin
|4 aut
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| 700 |
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|a Hoebe, Kasper
|e verfasserin
|4 aut
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|a Zuo, Jian-Ping
|e verfasserin
|4 aut
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|a Yuan, Chong
|e verfasserin
|4 aut
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|a Kono, Dwight H
|e verfasserin
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|a Theofilopoulos, Argyrios N
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|a Lawson, Brian R
|e verfasserin
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 147(2013), 2 vom: 12. Mai, Seite 133-43
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|g volume:147
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|u http://dx.doi.org/10.1016/j.clim.2013.02.018
|3 Volltext
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