Ultrasensitive Analysis of Binding Affinity of HIV Receptor and Neutralizing Antibody Using Solution-Phase Electrochemiluminescence Assay
Binding of a few ligand molecules with its receptors on cell surface can initiate cellular signaling transduction pathways, and trigger viral infection of host cells. HIV-1 infects host T-cells by binding its viral envelope protein (gp120) with its receptor (a glycoprotein, CD4) on T cells. Primary...
| Veröffentlicht in: | Journal of electroanalytical chemistry (Lausanne, Switzerland). - 1999. - 688(2013) vom: 01. Jan., Seite 53-60 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2013
|
| Zugriff auf das übergeordnete Werk: | Journal of electroanalytical chemistry (Lausanne, Switzerland) |
| Schlagworte: | Journal Article CD4 Electrochemiluminescence HIV receptors binding affinity binding constant gp120-CD4 ligand-receptor interaction neutralizing antibody protein-protein interaction |