Ultrasensitive Analysis of Binding Affinity of HIV Receptor and Neutralizing Antibody Using Solution-Phase Electrochemiluminescence Assay

Binding of a few ligand molecules with its receptors on cell surface can initiate cellular signaling transduction pathways, and trigger viral infection of host cells. HIV-1 infects host T-cells by binding its viral envelope protein (gp120) with its receptor (a glycoprotein, CD4) on T cells. Primary...

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Veröffentlicht in:Journal of electroanalytical chemistry (Lausanne, Switzerland). - 1999. - 688(2013) vom: 01. Jan., Seite 53-60
1. Verfasser: Xu, Xiao-Hong Nancy (VerfasserIn)
Weitere Verfasser: Wen, Zhaoyang, Brownlow, William J
Format: Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Journal of electroanalytical chemistry (Lausanne, Switzerland)
Schlagworte:Journal Article CD4 Electrochemiluminescence HIV receptors binding affinity binding constant gp120-CD4 ligand-receptor interaction neutralizing antibody protein-protein interaction ultrasensitive analysis