Estimating the mechanical properties of retinal tissue using contact angle measurements of a spreading droplet

When a drop of liquid is placed on the surface of a soft material, the surface deformation and the rate of spreading of the triple contact point is dependent on the mechanical properties of the substrate. This study seeks to use drop spreading behavior to infer the mechanical properties of soft biol...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1999. - 29(2013), 16 vom: 23. Apr., Seite 5080-4
1. Verfasser: Grant, Colin A (VerfasserIn)
Weitere Verfasser: Twigg, Peter C, Savage, Michael D, Woon, W Hong, Wilson, Mark, Greig, Denis
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't
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520 |a When a drop of liquid is placed on the surface of a soft material, the surface deformation and the rate of spreading of the triple contact point is dependent on the mechanical properties of the substrate. This study seeks to use drop spreading behavior to infer the mechanical properties of soft biological materials. As an illustration of the value of this technique we have compared the spreading behavior of a liquid droplet on two viscoelastic, soft materials, namely, an elastomer and a low concentration agar gel. The ratio of the mechanical properties of these soft materials obtained in this way is confirmed by atomic force microscopy (AFM) nanoindentation. By comparing the spreading behavior of a liquid on the retina with that of the same liquid on each of two viscoelastic materials, we can then estimate the elastic moduli of the retina: an estimate that is extremely difficult to carry out using AFM 
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700 1 |a Twigg, Peter C  |e verfasserin  |4 aut 
700 1 |a Savage, Michael D  |e verfasserin  |4 aut 
700 1 |a Woon, W Hong  |e verfasserin  |4 aut 
700 1 |a Wilson, Mark  |e verfasserin  |4 aut 
700 1 |a Greig, Denis  |e verfasserin  |4 aut 
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