|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM226030164 |
| 003 |
DE-627 |
| 005 |
20231224070515.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2013.02.008
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0753.xml
|
| 035 |
|
|
|a (DE-627)NLM226030164
|
| 035 |
|
|
|a (NLM)23518598
|
| 035 |
|
|
|a (PII)S1521-6616(13)00043-0
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Thornton, Margaret A
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis
|
| 264 |
|
1 |
|c 2013
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.05.2013
|
| 500 |
|
|
|a Date Revised 28.05.2019
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2013 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n=12), seasonal allergic rhinitis (n=7) and controls (n=10) were studied. Inferior nasal turbinate biopsies were obtained before, 8 and 48h after allergen challenge. Eight hours after allergen challenge eosinophils localized to nerves in both rhinitis groups; this was sustained through 48h. Bradykinin challenge, with secretion collection on the contralateral side, was performed to demonstrate nasal nerve reflexes. Twenty fourhours after allergen challenge, bradykinin induced a significant increase in secretions, indicating nasal hyperreactivity. Histological studies showed that nasal nerves expressed both vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 26 (CCL-26). Hence, after allergen challenge eosinophils are recruited and retained at nerves and so may be a mechanism for neural hyperreactivity
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Allergens
|2 NLM
|
| 650 |
|
7 |
|a CCL26 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Chemokine CCL26
|2 NLM
|
| 650 |
|
7 |
|a Chemokines, CC
|2 NLM
|
| 650 |
|
7 |
|a Vascular Cell Adhesion Molecule-1
|2 NLM
|
| 700 |
1 |
|
|a Akasheh, Nadim
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Walsh, Marie-Therese
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Moloney, Michael
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sheahan, Patrick O
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Smyth, Claire M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Walsh, Rory McConn
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Morgan, Ross M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Curran, David R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Walsh, Michael T
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gleich, Gerald J
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Costello, Richard W
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 147(2013), 1 vom: 01. Apr., Seite 50-57
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:147
|g year:2013
|g number:1
|g day:01
|g month:04
|g pages:50-57
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2013.02.008
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 147
|j 2013
|e 1
|b 01
|c 04
|h 50-57
|